It is also referred to as Runtime Code 1603. It occurs when McAfee VirusScan fails or crashes while it's running. It doesn't essentially indicate that the code was corrupt in some way, but just that it did not work during its run-time. It will appear as an bothersome notification on your screen unless it is handled and corrected properly in time.

https://threatprotections.com/mcafee-virus-scan-error/